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Inhibitors of Bile Salt Efflux Pump: Avoid concomitant use of inhibitors on the bile salt efflux pump (BSEP) like cyclosporine. Concomitant prescription drugs that inhibit canalicular membrane bile acid transporters such as the BSEP may well exacerbate accumulation of conjugated bile salts such as taurine conjugate of obeticholic acid during the l